Horvath Lab Biology of Aging and Epigenetic Clocks

Publications

The complete, current list is on Google Scholar; the machine-readable record is on ORCID. Below, a selection.

Selected

Universal DNA methylation age across mammalian tissues
Lu AT, Fei Z, Haghani A, et al., Horvath S. Nature Aging, 2023.
One formula for biological age across all mammals.
DNA methylation GrimAge strongly predicts lifespan and healthspan
Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Assimes TL, Ferrucci L, Horvath S. Aging, 2019.
GrimAge: the mortality-predicting clock.
An epigenetic biomarker of aging for lifespan and healthspan
Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S. Aging, 2018.
PhenoAge: a clock trained on clinical measures rather than chronological age.
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
Horvath S, Raj K. Nature Reviews Genetics, 2018.
A review of the field and a theory of what the clocks measure.
DNA methylation age of human tissues and cell types
Horvath S. Genome Biology, 2013.
The first multi-tissue epigenetic clock.
Epigenetic predictor of age
Bocklandt S, Lin W, Sehl ME, Sánchez FJ, Sinsheimer JS, Horvath S, Vilain E. PLoS ONE, 2011.
The saliva-based clock that started the program.